Immunological tolerance: transmission from mother to offspring

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Science  05 Sep 1975:
Vol. 189, Issue 4205, pp. 811-813
DOI: 10.1126/science.1162355


Mice born and raised by mothers made specifically unresponsive to heterologous erythrocytes by prior treatment with soluble extracts of these cells become themselves tolerant. Tolerance is achieved through nursing since normal neonates fostered by tolerant animals become tolerant, while animals born to tolerant mothers but nursed by normal mice are fully responsive.