Diphenylhydantoin: action of a common anticonvulsant on bursting pacemaker cells in Aplysia

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Science  19 Sep 1975:
Vol. 189, Issue 4207, pp. 1009-1011
DOI: 10.1126/science.1220006


A commonly used anticonvulsant, diphenylhydantoin (Dilantin), decreases the bursting pacemaker activity in certain cells of Aplysia. Dilantin decreases this bursting activity whether it is endogenous to the cell or induced by a convulsant agent. The sodium-dependent negative resistance characteristic which is essential for bursting behavior is reduced in the presence of Dilantin.