Antibodies that impair insulin receptor binding in an unusual diabetic syndrome with severe insulin resistance

Science  03 Oct 1975:
Vol. 190, Issue 4209, pp. 63-65
DOI: 10.1126/science.170678


Six patients with a unique form of diabetes associated with extreme insulin resistance have markedly reduced insulin binding to specific receptors on their circulating monocytes. When normal insulin receptors were exposed to serum or immunoglobulin fractions from three of these patients in vitro the specific binding defect was reproduced.