Complement-mediated bactericidal system: evidence for a new pathway of complement action

See allHide authors and affiliations

Science  17 Oct 1975:
Vol. 190, Issue 4211, pp. 278-280
DOI: 10.1126/science.1101380


The early components of human complement (C1, C4, and C2) plus certain serum euglobulins will kill pathogenic strains of Shigella sonnei. Serum from patients with hereditary C3 deficiencies and specific antiserums to C3, C5, and C6 were utilized to demonstrate the absence of requirements for late-acting complement components in this unusual bactericidal system.