Reports

Hemopoietic stem cells in human peripheral blood

Science  17 Oct 1975:
Vol. 190, Issue 4211, pp. 284-285
DOI: 10.1126/science.1179209

Abstract

A population of lymphocytes, separable from the great majority by virtue of their larger size and their failure to exhibit the rosetting characteristics of thymus-dependent lymphocytes and bursa-equivalent cells, possess true pluripotentiality. On culture in vivo they proliferate and differentiate into erythrocytic, granulocytic, and megakaryocytic progeny. This may be the first clear demonstration of the primitive progenitor blood cell in man.

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