Differentiation of red blood cells in vitro

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Science  31 Oct 1975:
Vol. 190, Issue 4213, pp. 471-473
DOI: 10.1126/science.1080882


Differentiation of red blood cells occurs in organ cultures of both livers and kidney tissue from tadpoles of the bullfrog Rana catesbeiana. Our evidence indicates that different red blood cell lines are produced by the two tissues and that these different cell lines contain different tadpole hemoglobins.