Transmission of Creutzfeldt-Jakob disease from man to the guinea pig

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Science  07 Nov 1975:
Vol. 190, Issue 4214, pp. 571-572
DOI: 10.1126/science.190.4214.571


Intracerebral and intraperitoneal inoculation of two guinea pigs with biopsy material from a patient with Creutzfeldt-Jakob disease produced a similar fatal encephalopathy characterized by status spongiosus 422 and 512 days after inoculation. Serial transmission of this disease from guinea pig to guinea pig was achieved in subsequent passages.