Transmission of Creutzfeldt-Jakob disease from man to the guinea pig

Science  07 Nov 1975:
Vol. 190, Issue 4214, pp. 571-572
DOI: 10.1126/science.190.4214.571


Intracerebral and intraperitoneal inoculation of two guinea pigs with biopsy material from a patient with Creutzfeldt-Jakob disease produced a similar fatal encephalopathy characterized by status spongiosus 422 and 512 days after inoculation. Serial transmission of this disease from guinea pig to guinea pig was achieved in subsequent passages.

Related Content