In vitro demonstration of an endothelial proliferative factor produced by neural cell lines

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Science  14 Nov 1975:
Vol. 190, Issue 4215, pp. 682-684
DOI: 10.1126/science.171768


Cultured endothelial cells exhibit a six- to tenfold increase in thymidine labeling index in response to a soluble factor elaborated by clonal cell lines of neural origin. This factor, endothelial proliferation factor, appears to be a unique property of tumor cells and may mediate the vascularization of these neoplasms.