Production of globules in mouse L cells penetrated with hamster sperms

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Science  14 Nov 1975:
Vol. 190, Issue 4215, pp. 684-686
DOI: 10.1126/science.171769


Globule formation has been observed in long-term cultures of mouse L cells penetrated with hamster spermatozoa. These numerous, uniform, and spherical structures are approximately 10 micrometers in diameter when formed, and are positive to stains specific for proteins and nucleic acids. They may be produced either by sperms within their target cells or by the cells in response to penetration by the spermatozoa.