Spleen cells transmit osteopetrosis in mice

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Science  21 Nov 1975:
Vol. 190, Issue 4216, pp. 785-787
DOI: 10.1126/science.1198094


Osteopetrosis was induced in lethally irradiated, normal mice of grey-lethal and microphthalmic stocks by cell infusions prepared from the spleens of osteopetrotic littermates. Failure of skeletal remodeling became evident within a few weeks after transplantation as calcified cartilage and bone accumulated excessively in the active metaphyses of the long bones. The massive lesions produced were extensively infiltrated with abnormal osteoclasts.