Reports

Differentiation of erythroleukemic cells in the presence of inhibitors of DNA synthesis

Science  28 Nov 1975:
Vol. 190, Issue 4217, pp. 893-894
DOI: 10.1126/science.1059262

Abstract

Erythroid differentiation can be readily induced by butyric acid in cultured erythroleukemic cells in the presence of inhibitors of DNA synthesis and in the absence of cell division. This result appears to rule out more complex models for globin gene expression which require gene replication or cell division (or both).

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