Cyclic AMP-dependent protein kinase: pivotal role in regulation of enzyme induction and growth

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Science  28 Nov 1975:
Vol. 190, Issue 4217, pp. 896-898
DOI: 10.1126/science.171770


Dibutyryl cyclic adenosine 3',5'-monophosphate (cyclic AMP) produces phosphodiesterase induction, growth arrest, and cytolysis in S49 lymphoma cells. The striking parallelism between protein kinase activity that is dependent on cytosol cyclic AMP and cellular responses to dibutyryl cyclic AMP in wild-type cells and three classes of clones resistant to cyclic AMP indicates that protein kinase mediates cyclic AMP regulation of growth and enzyme induction in S49 cells.