Biogenesis of erythropoietin: evidence for pro-erythropoietin in a subcellular fraction of kidney

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Science  28 Nov 1975:
Vol. 190, Issue 4217, pp. 910-912
DOI: 10.1126/science.1242543


The light mitochondrial fraction of hypoxic rodent kidneys, called the renal erythropoietic factor, contains erythropoietin in a pro, or active form. Erythropoietin is released from this inactive form when the renal erythropoietic factor is incubated with normal serum. The biogenesis of erythropoietin possibly involves a system in kidney reminiscent of the proinsulin-insulin system in pancreas.