Thymus: central role in the immune system of the frog

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Science  12 Dec 1975:
Vol. 190, Issue 4219, pp. 1101-1103
DOI: 10.1126/science.190.4219.1101


In the leopard frog (Rana pipiens), the thymus profoundly influences immunologic development by providing virtually all the progenitor lymphocytic cells for the bone marrow and other peripheral lymphoid organs. The thymus houses a self-perpetuating population of lymphopoietic cells that originally self-differentiated in that gland.