Infectious etiology of neuritic (senile) plaques in mice

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Science  12 Dec 1975:
Vol. 190, Issue 4219, pp. 1108-1110
DOI: 10.1126/science.1237933


Brains of inbred female VM mice infected with scrapie agent were studied with the use of the Bodian silver impregnation method and by electron microscopy. In brains affected with scrapie, after an incubation period of between 587 and 655 days, numerous primitive, classical, and amyloid plaques were found. No plaques of any type were seen in the control mice.