Tumorigenicity of mouse-human diploid hybrids in nude mice

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Science  19 Dec 1975:
Vol. 190, Issue 4220, pp. 1200-1202
DOI: 10.1126/science.173020


Somatic cell hybrids between normal mouse cells and simian virus 40 (SV40)-transformed human cells, which contained a diploid complement of mouse chromosomes and the human chromosome 7 carrying the genome of SV40, were tumorigenic in nude mice. One single copy of human chromosome 7 per hybrid cell appeared to be sufficient for the tumorigenicity of the hybrids.