Minor salivary glands as a major source of secretory immunoglobin A in the human oral cavity

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Science  19 Dec 1975:
Vol. 190, Issue 4220, pp. 1206-1209
DOI: 10.1126/science.1198107


Secretory immunoglobulin A is the predominant immunoglobulin in labial minor salivary gland secretions. Its mean concentration is four times higher in these secretions than in parotid gland secretion. The minor salivary glands can produce 30 to 35 percent of the immunoglobulin A that enters the oral cavity. This, together with the potential accessibility of these glands to antigenic stimulation, suggest that they may be an important source of the immune factors that are involved in the regulation of the microorganisms in the oral environment.