Lipoprotein and lecithin: cholesterol acyltransferase changes in galactosamine-induced rat liver injury

Science  26 Dec 1975:
Vol. 190, Issue 4221, pp. 1302-1304
DOI: 10.1126/science.812181


Abnormal lipoproteins and drcreased lecithin: cholesterol acyltransferase activity are found in rat plasma following intraperitoneal injection of D-galactosamine. The changes observed, including absence of alpha-lipoprotein and the presence of lipoproteins rich in phospholipid and unesterified cholesterol but deficient in cholesteryl esters, are remarkably similar to changes found in human pathologic states of lecithin: cholesterol acyltransferase deficiency. When examined by electron microscopy, all of the major lipoprotein classes isolated by ultracentrifugation showed morphological abnormalities including the formation of rouleaus consisting of disk-shaped particles.