Opsin structure probed by raman spectroscopy of photoreceptor membranes

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Science  19 Mar 1976:
Vol. 191, Issue 4232, pp. 1176-1178
DOI: 10.1126/science.1257742


The first nonresonance Raman spectra of photoreceptor membranes are presented. Information about the membrane protein, opsin, and the membrane phospholipids can be deduced. Opsin appears to contain alpha-helical structure but little beta structure. The tyrosine residues are predominantly hydrogen bonded, and disulfide bonds, if they are present, are not in the normal gauche-gauche configuration.