Phylogeny of DNA polymerase-beta

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Science  19 Mar 1976:
Vol. 191, Issue 4232, pp. 1183-1185
DOI: 10.1126/science.769158


Analyses of various organisms for DNA polymerase-beta activity show that the enzyme is widely distributed in cells from multicellular animals but absent in bacteria, plants, and protozoa. These results suggest that DNA polymerase-beta may have evolved with the development of metazoan forms. Further evolutionary changes of the enzyme protein may account for some of the minor differences in properties of the enzyme in various organisms.