Elimination of the sarcoma genome from murine sarcoma virus transformed cat cells

Science  26 Mar 1976:
Vol. 191, Issue 4233, pp. 1264-1266
DOI: 10.1126/science.1257745


Cat cells transformed by Moloney murine sarcoma virus contain virus-specific sequences in their RNA and DNA. Cloned, spontaneous revertant cell lines derived from clones of these cells had no evidence of the sarcoma genome in the cell RNA or DNA as judged by RNA-complementary DNA or DNA-complementary DNA hybridizations. ?This is apparently the first report of loss of a transforming genome in a revertant cell line.