Human glyceraldehyde-3-phosphate dehydrogenase in man-rodent somatic cell hybrids

Science  02 Apr 1976:
Vol. 192, Issue 4234, pp. 54-56
DOI: 10.1126/science.176725


The human enzyme glyceraldehyde-3-phosphate dehydrogenase (GAPDH) forms heteropolymers with the rodent enzyme in man-rodent somatic cell hybrids. A gene specifying GAPDH is syntenic with the genes specifying the glycolytic enzymes triosephosphate isomerase (TPI) and lactate dehydrogenase B (LDH-B). The synteny of GAPDH, TPI, and LDH-B is the first evidence for the syntenic association of human genes that specify enzymes of the Embden-Meyerhof glycolytic pathway.