Tin: a potent inducer of heme oxygenase in kidney

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Science  02 Apr 1976:
Vol. 192, Issue 4234, pp. 60-62
DOI: 10.1126/science.1257757


Tin greatly enhances heme breakdown in kidney, thus impairing heme-dependent cellular functions, such as cytochrome P-450 mediated drug biotransformation. This novel action of the metal results from a potent induction effect on heme oxygenase, the enzyme that catalyzes heme oxidation in microsomes. The possible toxicological implications of this tin effect in the kidney merit further investigation.