Theiler's virus-induced demyelination: prevention by immunosuppression

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Science  02 Apr 1976:
Vol. 192, Issue 4234, pp. 62-64
DOI: 10.1126/science.176726


The effect of immunosuppression with cyclophosphamide and rabbit antiserum to mouse thymocytes on demyelination induced by Theiler's virus in SJL/J mice was ascertained from Epon-embedded sections (1 micrometer) of the central nervous system. Immunosuppression not only eliminated mononuclear cell infiltrates in the spinal cord white matter, but it also prevented the occurrence of demyelination. These results suggest that demyelination in this infection is immune-mediated.