Neural properties of cultured human endocrine tumor cells of proposed neural crest origin

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Science  28 May 1976:
Vol. 192, Issue 4242, pp. 902-904
DOI: 10.1126/science.179139


Cells from human endocrine tumors of proposed neural crest origin--five pheochromocytomas, two medullary carcinomas of the thyroid, and two bronchial carcinoids--were grown in monolayer culture. Cells from all nine tumors, including epithelial forms of medullary carcinoma of the thyroid and bronchial carcinoid cells, and epithelial and neuron-like pheochromocytoma cells demonstrated all-or-nothing, short-duration action potentials.