Vasoactive intestinal polypeptide: abundant immunoreactivity in neural cell lines and normal nervous tissue

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Science  28 May 1976:
Vol. 192, Issue 4242, pp. 907-908
DOI: 10.1126/science.1273576


Vasoactive intestinal polypeptide immunoreactivity is present in high concentrations in clonal lines of neuronal and glial origin. The central nervous system and sympathetic ganglia are also rich in the peptide. The findings suggest that this peptide, hitherto thought limited to the gastrointestinal tract, is widely distributed in neural tissue and may have broad physiological significance.