Reports

Monoamine oxidase activity decreased in cells lacking hypoxanthine phosphoribosyltransferase activity

Science  04 Jun 1976:
Vol. 192, Issue 4243, pp. 1018-1020
DOI: 10.1126/science.1273584

Abstract

The Lesch-Nyhan syndrome in humans is characterized by lack of hypoxanthine phosphoribosyltransferase activity and neurologic abnormalities that suggest changes in catecholamine metabolism. Monoamine oxidase, which degrades biogenic amines, has decreased activity in noradrenergic murine neuroblastoma cell lines lacking hypoxanthine phosphoribosyltransferase activity and in skin fibroblasts from patients with the Lesch-Nyhan syndrome.

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