Oncogenic transformation of human embryo lung cells by human cytomegalovirus

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Science  11 Jun 1976:
Vol. 192, Issue 4244, pp. 1134-1137
DOI: 10.1126/science.179143


Persistent infection of human embryo lung fibroblasts with a genital isolate of cytomegalovirus resulted in oncogenic transformation of these cells. Immunofluorescence techniques detected virus-specific antigens, while microcytotoxicity tests established that the transformed cells share a membrane antigen with hamster cells transformed by inactivated cytomegalovirus. The transformed human cells induced progressively growing tumors in weanling athymic nude mice.