Increased sarcoma virus RNA in cells transformed by leukemia viruses: model for leukemogenesis

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Science  11 Jun 1976:
Vol. 192, Issue 4244, pp. 1143-1145
DOI: 10.1126/science.179144


A morphologically flat revertant of mink cells nonproductively infected with Moloney sarcoma virus exhibited contact inhibition and lacked detectable sarcoma virus RNA. Superinfection by usually nontransforming type C mammalian leukemia-causing viruses induced transformation and increased sarcoma virus RNA. The results suggest a model for leukemogenesis in animals by increasing, during replication of usually nontransforming leukemia viruses, the levels of RNA from potentially oncogenic cell or integrated virus transforming genes.