Bone cells in culture: morphologic transformation by hormones

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Science  25 Jun 1976:
Vol. 192, Issue 4246, pp. 1340-1343
DOI: 10.1126/science.1273593


Hormones and purine nucleosides and nucleotides induced cultured bone cells to transform transiently from a spherical to a stellate shape. Cytochalasin B also induced the transformation. The change was blocked by colchicine and vinblastine, but not by lumicolchicine or cycloheximide. This morphologic transformation may provide a dynamic model of hormone action and bone cell modulation in vitro.