Analgesia mediated by a direct spinal action of narcotics

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Science  25 Jun 1976:
Vol. 192, Issue 4246, pp. 1357-1358
DOI: 10.1126/science.1273597


Narcotic analgetics administered directly into the spinal subarachnoid space of the rat via a chronically inserted catheter produce a potent analgesia that can be antagonized by naloxone. The narcotics, acting only at the spinal level, changed cord function to block not only spinal reflexes but also the operant response to painful stimuli.