Reports

Ethanol-induced depletion of cerebellar guanosine 3',5' -cyclic monophosphate

Science  02 Jul 1976:
Vol. 193, Issue 4247, pp. 58-59
DOI: 10.1126/science.180596

Abstract

Single doses of ethanol a severe depletion (95 percent) of cerebellar guanosine 3',5' -cyclic monophosphate (cyclic GMP) within 1 hour after administration. The degree of this depletion is dose-dependent and is a function of the amount of ethanol in the blood. Interactions between ethanol and cyclic GMP may account for some of the intoxicating properties of ethanol.

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