Memory: proline induces retrograde amnesia in chicks

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Science  16 Jul 1976:
Vol. 193, Issue 4249, pp. 242-244
DOI: 10.1126/science.945612


Intracerebral injection of L-proline, 1 minute after one-trial avoidance training of chicks, impaired memory 24 hours later. Chicks injected with proline 1 or 4 hours after training and controls injected with L-isoleucine at intervals after training, showed no impairment of memory 24 hours after training. The retrograde impairment of long-term memory induced by proline occurred without the convulsions or electrographic events usually associated with retrograde amnesic treatments.