Functional development of prefrontal cortex in rats continues into adolescence

Science  23 Jul 1976:
Vol. 193, Issue 4250, pp. 335-336
DOI: 10.1126/science.935872


Bilateral removal of the sulcal prefrontal cortex in rats at 60 days of age and older results in aphagia and adipsia, but removal of this area before 60 days of age does not affect food or water regulation. Apparently the development of the role of this neocortical region in feeding and drinking continues well beyond the time of weaning in the rat.