Insulin binding to cultured human fibroblasts increases with normal and precocious aging

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Science  30 Jul 1976:
Vol. 193, Issue 4251, pp. 412-415
DOI: 10.1126/science.180604


Specific and nonspecific [125I]insulin binding and concentration of unlabeled hormone producing 50 percent competition with 1.0 nanomolar [125I]insulin for specific binding sites correlated positively with age of fibroblast donors. Cells from four children with precocious aging--three with progeria and one with Rothmund syndrome-resembled those from the chronologically old.