Asparaginase entrapped in red blood cells: action and survival

See allHide authors and affiliations

Science  20 Aug 1976:
Vol. 193, Issue 4254, pp. 681-683
DOI: 10.1126/science.821145


As a strategy to avoid serious allergic reactions to the antitumor agent asparaginase, this enzyme was entrapped in autologous red blood cells before intravenous injection into monkeys. Additional advantages of this approach are prolonged enzyme half-life and targeting of this agent into the reticuloendothelial system.