Binding of C-reactive protein to antigen-induced but not mitogen-induced T lymphoblasts

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Science  20 Aug 1976:
Vol. 193, Issue 4254, pp. 685-687
DOI: 10.1126/science.1085034


The C-reactive protein (CRP), an acute phase reactant which binds selectively to T (thymus-derived) lymphocytes, was found to bind to lymphoblasts formed upon stimulation with antigens but not with mitogens. Binding of CRP thus serves as a marker for antigen-reactive (-reacted) as opposed to mitogen-reative (-reacted) T cells, suggesting that these represent separate subpopulations, and supports the developing concept that CRP play an important role in the regulation of responses critical to inflammation, host defense, and tissue repair.