Acetylcholine hot spots: development on myotubes cultured from aneural limb buds

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Science  03 Sep 1976:
Vol. 193, Issue 4256, pp. 915-917
DOI: 10.1126/science.948754


The hypothesis that neural induction plays a role in the development of acetylcholine hot spots (high-sensitivity regions) was tested by electrophysiological mapping of the distribution of acetylcholine sensitivity of myotubes derived from aneural hindlimb buds of chick embryos. Hot spots were found. Therefore, hot spot development is not dependent on prior contact with nerve processes.