Cortisol stimulation of parathyroid hormone secretion by rat parathyroid glands in organ culture

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Science  10 Sep 1976:
Vol. 193, Issue 4257, pp. 1015-1017
DOI: 10.1126/science.948759


Addition of cortisol (10(-6) to 10(-8) M) and related glucocorticoid congeners to cultures of rat parathyroid glands stimulated dose-related increases in parathyroid hormone secretion; the addition of deoxycorticosterone or cortexolone was without effect. Cortexolone, however, inhibited the stimulatory activity of cortisol when both were added to the culture medium. This direct stimulatory effect of cortisol on parathyroid gland secretion may account in part for the increased concentration of parathyroid hormone in the serum of cortisol-treated animals.