Myosin synthesis increased by electrical stimulation of skeletal muscle cell cultures

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Science  17 Sep 1976:
Vol. 193, Issue 4258, pp. 1152-1154
DOI: 10.1126/science.959833


When cultures of skeletal muscle cells of the chick embryo are subjected to repetitive, electrical stimulation, the contractions increase the amount of protein produced by these cells. The increase is greater for contractile proteins such as myosin heavy chain than for total cellular protein. This demonstrates that in a culture system of skeletal muscle cells that have differentiated in the absence of innervation, one can elicit the protein synthetic response associated with skeletal muscle hypertrophy in vivo.