Flow-field-flow fractionation: a versatile new separation method

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Science  24 Sep 1976:
Vol. 193, Issue 4259, pp. 1244-1245
DOI: 10.1126/science.959835


Flow-field-fractionation is a new separation technique that seems likely to have broad applicability. Its theoretical scope includes any solute for which one can find a solvent and a semipermeable membrane. The principles on which the technique is based are presented. Some experiments with polystyrene beads, viruses, and proteins verify that retention depends solely on diffusion coefficients.