Cytochrome P-450 and drug metabolism in Trypanosoma cruzi: effects of phenobarbital

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Science  08 Oct 1976:
Vol. 194, Issue 4261, pp. 195-197
DOI: 10.1126/science.785602


The epimastigotes of Trypanosoma cruzi hydroxylate drugs at substantial rates. The activity, which is of the mixed-function oxidase type, is increased by phenobarbital and is inhibited by CO, SKF 525-A, and metyrapone. The hydroxylation is paralleled by increases in free and membrane-bound ribosomes.