Nuclear inclusions in Paget's disease of bone

Science  08 Oct 1976:
Vol. 194, Issue 4261, pp. 201-202
DOI: 10.1126/science.959849


The ultrastructure of bone cells was examined in biopsies from 18 patients with Paget's disease of bone and from 60 patients with a variety of other bone diseases. A characteristic nuclear inclusion was found in the osteoclasts of each patient with Paget's disease. The nuclear inclusion most closely resembles viral nucleocapsids of the measles type.