Thyroid hormones: effect of physiological concentrations on cultured cardiac cells

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Science  08 Oct 1976:
Vol. 194, Issue 4261, pp. 202-204
DOI: 10.1126/science.183268


Cultured cardiac cells prepared from newborn rat heart will respond in vitro to physiological concentrations of L-triiodothyronine. The cells are grown in a culture medium that contains hypothyroid calf serum. A dose response relationship of L-triiodothyronine indicates that this system may be a useful model for elucidation of the mechanism of thyroid hormone effects on the heart.