Trypanosomiasis: an approach to chemotherapy by the inhibition of carbohydrate catabolism

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Science  08 Oct 1976:
Vol. 194, Issue 4261, pp. 204-206
DOI: 10.1126/science.986688


When the infected mammalian host of Trypanosoma brucei brucei is injected with a solution of the iron chelator salicyl hydroxamic acid and glycerol, the aerobic and anaerobic glucose catabolism of the parasite is blocked and the parasite is rapidly destroyed.