Reinnervation of dentate gyrus by homologous afferents following entorhinal cortical lesions in adult rats

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Science  22 Oct 1976:
Vol. 194, Issue 4263, pp. 426-428
DOI: 10.1126/science.982024


Granule cells of the rat dentate gyrus which are denervated by unilateral destruction of the entorhinal cortex are reinnervated in part by proliferation of surviving pathways from the contralateral entorhinal cortex. The cells of origin of these lesion-induced projections were identified by retrograde labeling with horseradish peroxidase and were the same cell type which normally project to the ipsilateral dentate gyrus