Activation of histone gene transcription by nonhistone chromosomal phosphoproteins

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Science  22 Oct 1976:
Vol. 194, Issue 4263, pp. 428-431
DOI: 10.1126/science.982025


Hybridization analysis of RNA transcripts from HeLa S3 cell chromatin to histone complementary DNA indicates that a chromosomal phosphoprotein fraction activates transcription of histone messenger RNA sequences in vitro with chromatin from a phase in the cell cycle when histone genes are normally silent.