Nuclear and mitochondrial DNA replication during zygote formation and maturation in yeast

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Science  22 Oct 1976:
Vol. 194, Issue 4263, pp. 433-435
DOI: 10.1126/science.790566


Nuclear and mitochondrial DNA replication were monitered during the development of synchronous yeast zygotes. Purified first zygotic buds were also analyzed. Nuclear DNA replicated discontinuously but coincidently with bud initiation, while mitochondrial DNA replicated throughout the zygotic formation and maturation period. First zygotic buds contained the diploid level of both nuclear and mitochondrial DNA.