Reports

Cholinergic stimulation of the rat hypothalamus: effects of liver glycogen synthesis

Science  29 Oct 1976:
Vol. 194, Issue 4264, pp. 535-536
DOI: 10.1126/science.9692

Abstract

Cholinergic stimulation of the lateral hypothalamic neurons with intrahypothalamic microinjections of acetylcholine or carbachol caused a marked increase in the content of the active form of glycogen (starch) synthase in the liver. Total activity of the enzyme (active plus inactive forms) was not increased significantly. The lowest effective dose of acetylcholine was 5 X 10(-10) mole, and the optimum dose was 5 X 10(-9) mole. Similar applications of other neurotransmitters, such as norepinephrine, dopamine, serotonin, and gamma-aminobutyric acid, did not affect the enzyme's activity.

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