Regulation of acetylcholine synthesis: does cytoplasmic acetylcholine control high affinity choline uptake?

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Science  05 Nov 1976:
Vol. 194, Issue 4265, pp. 635-637
DOI: 10.1126/science.982031


When brain synaptosomes are obtained from animals that have been injected intravenously with [2H4]choline 1 minute before being killed, their high affinity [3H] choline uptake is correlated inversely with their acetylcholine content and directly with the rate at which they synthesize [2H4]acetylcholine. The control of such choline uptake by the cytoplasmic acetylcholine concentration is proposed as a mechanism regulating acetylcholine synthesis in cholinergic nerve terminals.